Obese inducing brain mechanism

The research group of Professor Masaharu Noda, Associate Professor Takafumi Shintani, and a graduate student Satoru Higashi of the National Institute for Basic Biology (NIBB) demonstrated that protein tyrosine phosphatase receptor type J (PTPRJ) inhibits leptin signaling and that induction of PTPRJ in the hypothalamus is a cause of leptin resistance. They showed that Ptprj is expressed in hypothalamic neurons together with leptin receptors, and that PTPRJ inhibits activation of the leptin receptor through dephosphorylation of JAK2, a protein tyrosine kinase associated with the leptin receptor.
Ptprj-deficient (Ptprj-KO) mice showed no growth retardation, but exhibited lower weight gain, because of a lower food intake and a lower adiposity, than wild-type (WT) mice. Importantly, PTPRJ expression in the hypothalamus was up-regulated by diet-induced obesity, and, thus, diet-induced leptin resistance did not occur in Ptprj-KO mice. Furthermore, the overexpression of PTPRJ in the hypothalamus induced leptin resistance in lean mice. These results strongly indicate that PTPRJ plays critical roles in the development of leptin resistance. The inhibition of PTPRJ may be a potential strategy for improving obesity.
for more information visit our product website:Buy Manforce 100 mg Online
Location: United States

Comments

Post a Comment

Popular posts from this blog

Synaptic receptor mobility: Discovery of a new mechanism for controlling memory

Communication between neurons passes through over one million billion synapses, tiny structures the tenth of the width of a single hair, in an extremely complex process. Synaptic plasticity -- the ability of synapses to adapt in response to neuronal activity -- was discovered nearly 50 years ago, leading the scientific community to identify it as a vital functional component of memorization and learning. Neurotransmitter receptors -- found at the synapse level -- play a key role in the transmission of nerve messages. A few years ago, the team of researchers in Bordeaux discovered that neurotransmitter receptors were not immobile as thought previously, but in a constant state of agitation. They posited that controlling this agitation through neuronal activity could modulate the effectiveness of synaptic transmission by regulating the number of receptors present at a given time in a synapse. The new research has taken the two teams further in their understanding of the basic mecha...
Read more

Antidepressants associated with significantly elevated risk of death, researchers find

t's widely known that brain serotonin affects mood, and that most commonly used antidepressant treatment for depression  blocks the absorption of serotonin by neurons. It is less widely known, though, that all the major organs of the body -- the heart, kidneys, lungs, liver -- use serotonin from the bloodstream. Antidepressants block the absorption of serotonin in these organs as well, and the researchers warn that antidepressants could increase the risk of death by preventing multiple organs from functioning properly. The researchers reviewed studies involving hundreds of thousands of people and found that antidepressant users had a 33% higher chance of death than non-users. Antidepressant users also had a 14% higher risk of cardiovascular events, such as strokes and heart attacks. The findings were published in the journal  Psychotherapy and Psychosomatics . "We are very concerned by these results. They suggest that we shouldn't be taking antidepressant drugs wi...
Read more